Article
Analysis of CYP2C19 Genetic Polymorphism in a Large Ethnic Hakka Population in Southern China.
Medical science monitor : international medical journal of experimental and clinical research - 30 Dec 2017
Zhong Zhixiong, Hou Jingyuan, Li Bing, Zhang Qifeng, Liu Sudong, Li Cunren, Liu Zhidong, Yang Min, Zhong Wei, Zhao Pingsen
Abstract excerpt
BACKGROUND Cytochrome P450 (CYP) 2C19 is an enzyme involved in the bioactivation of various important therapeutic drugs, from pro-drugs to an active inhibitor of platelet action. Variants in the CYP2C19 gene influence the pharmacokinetics and clinical response to antiplatelet drugs such as clopidogrel; however, there is no available data about the genetic variation of CYP2C19 in the Hakka population in China....
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