Article
Evaluation of the relationship between polymorphisms in CYP2C19 and the single-dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study.
Clinical and translational science - 1 Jun 2022
Zhou Shuang, Xie Ran, Zhang Xiaodan, He Xu, Huang Jie, Jungang Yin, Liao Man, Ding Ying, Yang Dandan, Liu Ying, Zhang Qian, Yang Guoping, Liu Fang, Guan Shengjiang, He Qing, Lou Honggang, Gong Fengyun, Meng Xianmin, Xiang Qian, Zhao Xia, Cui Yimin
Abstract excerpt
The aim of this study was to evaluate the relationship between polymorphisms in CYP2C19 and the single-dose pharmacokinetics (PKs) of omeprazole in healthy Chinese volunteers. A 20 mg single dose of omeprazole (Losec) enteric-coated capsules or tablets was orally administered to 656 healthy subjects from eight subcenters. The polymorphic alleles of CYP2C19*2, *3, and *17 were determined by Sanger sequencing and...
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