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Article

Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers.

Journal of Korean medical science - 1 May 2017

Park Sunny, Hyun Yang Jin, Kim Yu Ran, Lee Ju Hyun, Ryu Sunae, Kim Jeong Mi, Oh Woo Yong, Na Han Sung, Lee Jong Gu, Seo Doo Won, Hwang In Yeong, Park Zewon, Jang In Jin, Oh Jaeseong, Choi Seung Eun

Abstract excerpt

The aim of this study was to examine the effects of CYP2C19*2 and *3 genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses. Twenty-four healthy Korean volunteers were enrolled and given 20 mg omeprazole orally once daily for 8 days. The genotypes of CYP2C19 single nucleotide polymorphisms (SNPs) (*2, *3, and *17) were screened. The plasma concentrations of omeprazole,...

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Identifiers

PMID: 28378544
DOI: 10.3346/jkms.2017.32.5.729
PMCID: PMC5383603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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