Article
CYP2C19 activity comparison between Swedes and Koreans: effect of genotype, sex, oral contraceptive use, and smoking.
European journal of clinical pharmacology - 1 Sept 2010
Ramsjö Margareta, Aklillu Eleni, Bohman Lilleba, Ingelman-Sundberg Magnus, Roh Hyung-Keun, Bertilsson Leif
Abstract excerpt
OBJECTIVES: To compare CYP2C19 enzyme activity between Swedes and Koreans controlling for the effect of CYP2C19 genotype, sex, oral contraceptive use, and smoking habits. METHODS: CYP2C19 activity was determined in 185 healthy Swedish and 150 Korean subjects as the omeprazole/5-hydroxyomeprazole ratio (metabolic ratio; MR) using high-performance liquid chromatography. Genotyping was performed by PCR using Taqman...
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