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Article

Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients.

European journal of clinical pharmacology - 1 Nov 2009

Ohno Masako, Yamamoto Akiko, Ono Ayumu, Miura Genta, Funamoto Masanobu, Takemoto Yasuhiko, Otsu Kinya, Kouno Yasushi, Tanabe Tomoko, Masunaga Yuiko, Nonen Shinpei, Fujio Yasushi, Azuma Junichi

Abstract excerpt

OBJECTIVE: The aim of this study was to investigate the influence of clinical and genetic factors on warfarin dose requirements in the Japanese population. METHODS: We enrolled 125 patients on stable warfarin anticoagulant therapy with an international normalized ratio maintained between 1.5 and 3.0. PCR-based methods were performed to analyze genetic polymorphisms in the genes pharmacokinetically and...

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Source

Identifiers

PMID: 19582440
DOI: 10.1007/s00228-009-0685-9

Genes

VKORC1
GGCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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