Effect of genetic factors on the interindividual variability of warfarin dosage requirements in Japanese patients after adjusting for renal function.

doi:10.1691/ph.2024.4546

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Article

Effect of genetic factors on the interindividual variability of warfarin dosage requirements in Japanese patients after adjusting for renal function.

Die Pharmazie - 1 Aug 2024

Nishiba H, Nagamine A, Yashima H, Takahashi Y, Higuchi Y, Sekizaki N, Nakamura H, Araki T, Takama N, Koitabashi N, Nakajima T, Kaneko Y, Ohyama Y, Yokoyama T, Imai K, Kurabayashi M, Yamamoto K, Obayashi K

Abstract excerpt

Renal function significantly influences the appropriate warfarin dosage. However, studies investigating the impact of genetic factors on warfarin dosage, considering renal function, are limited. This study aimed to assess the role of genetic polymorphisms in VKORC1, CYP2C9, CYP2C19, CYP4F2, GGCX, and APOE in warfarin dosage adjustment considering renal function. A total of 108 outpatients receiving warfarin...

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