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Article

Association of VKORC1 and CYP2C9 single-nucleotide polymorphisms with warfarin dose adjustment in Saudi patients.

Drug metabolism and personalized therapy - 1 Dec 2022

Holail Jasmine, Mobarak Reem, Al-Ghamdi Bandar, Aljada Ahmad, Fakhoury Hana

Abstract excerpt

OBJECTIVES: Despite its wide usage, warfarin therapy remains challenging due to its narrow therapeutic index, inter-individual response variability, and risk of bleeding. Previous reports have suggested that polymorphisms in VKORC1 and CYP2C9 genes could influence warfarin therapy. Herein, we investigated whether VKORC1 -1173C>T, CYP2C9*2, and CYP2C9*3 gene polymorphisms are associated with warfarin dose...

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Source

Identifiers

PMID: 36476275
DOI: 10.1515/dmpt-2022-0108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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