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Article

A chromosomal memory triggered by Xist regulates histone methylation in X inactivation.

PLoS biology - 1 Jul 2004

Kohlmaier Alexander, Savarese Fabio, Lachner Monika, Martens Joost, Jenuwein Thomas, Wutz Anton

Abstract excerpt

We have elucidated the kinetics of histone methylation during X inactivation using an inducible Xist expression system in mouse embryonic stem (ES) cells. Previous reports showed that the ability of Xist to trigger silencing is restricted to an early window in ES cell differentiation. Here we show that this window is also important for establishing methylation patterns on the potential inactive X chromosome. By...

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Share to Chromatin Immunoprecipitation
Share to Dosage Compensation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

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Share to RNA, Long Noncoding

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Identifiers

PMID: 15252442
DOI: 10.1371/journal.pbio.0020171
PMCID: PMC449785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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