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Article

Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis.

Nature cell biology - 1 Aug 2009

Singh Rakesh Kumar, Kabbaj Marie-Helene Miquel, Paik Johanna, Gunjan Akash

Abstract excerpt

Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromosomal histones are stable, excess (non-chromatin bound) histones are rapidly degraded in a Rad53 (radiation sensitive 53) kinase-dependent manner in Saccharomyces...

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Identifiers

PMID: 19578373
DOI: 10.1038/ncb1903
PMCID: PMC2720428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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