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Article

Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans.

Cell cycle (Georgetown, Tex.) - 17 Aug 2016

Wike Candice L, Graves Hillary K, Wason Arpit, Hawkins Reva, Gopalakrishnan Jay, Schumacher Jill, Tyler Jessica K

Abstract excerpt

The cell tightly controls histone protein levels in order to achieve proper packaging of the genome into chromatin, while avoiding the deleterious consequences of excess free histones. Our accompanying study has shown that a histone modification that loosens the intrinsic structure of the nucleosome, phosphorylation of histone H3 on threonine 118 (H3 T118ph), exists on centromeres and chromosome arms during...

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Identifiers

PMID: 27248858
DOI: 10.1080/15384101.2016.1192728
PMCID: PMC4993543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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