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Article

Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.

PloS one - 1 Jan 2012

Singh Rakesh Kumar, Gonzalez Melanie, Kabbaj Marie-Helene Miquel, Gunjan Akash

Abstract excerpt

Core histone proteins are essential for packaging the genomic DNA into chromatin in all eukaryotes. Since multiple genes encode these histone proteins, there is potential for generating more histones than what is required for chromatin assembly. The positively charged histones have a very high affinity for negatively charged molecules such as DNA, and any excess of histone proteins results in deleterious effects...

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Identifiers

PMID: 22570702
DOI: 10.1371/journal.pone.0036295
PMCID: PMC3343073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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