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Article

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast.

Nature - 4 Jul 2002

Sun Zu-Wen, Allis C David

Abstract excerpt

In eukaryotes, the DNA of the genome is packaged with histone proteins to form nucleosomal filaments, which are, in turn, folded into a series of less well understood chromatin structures. Post-translational modifications of histone tail domains modulate chromatin structure and gene expression. Of these, histone ubiquitination is poorly understood. Here we show that the ubiquitin-conjugating enzyme Rad6 (Ubc2)...

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PMID: 12077605
DOI: 10.1038/nature00883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast.PMID 12077605Read ↗

Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation.Semantic proximity Read ↗

Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.Semantic proximity Read ↗

Defective RNA Polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 PathwaySemantic proximity Read ↗

Paf1 complex subunit Rtf1 stimulates H2B ubiquitylation by interacting with the highly conserved N-terminal helix of Rad6Semantic proximity Read ↗

Novel trans-tail regulation of H2B ubiquitylation and H3K4 methylation by the N terminus of histone H2A.Semantic proximity Read ↗

Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway.Semantic proximity Read ↗

Genes of the month: H3.3 histone genes: H3F3A and H3F3B.Semantic proximity Read ↗

Monoubiquitination of histone H2B is intrinsic to the Bre1 RING domain-Rad6 interaction and augmented by a second Rad6-binding site on Bre1.Semantic proximity Read ↗

The role of histone ubiquitylation and deubiquitylation in gene expression as determined by the analysis of an HTB1(K123R) Saccharomyces cerevisiae strain.Semantic proximity Read ↗

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation.Semantic proximity Read ↗

Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals.Semantic proximity Read ↗

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.Semantic proximity Read ↗

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