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Article

Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae.

PLoS genetics - 1 Jan 2012

Gallego-Sánchez Alfonso, Andrés Sonia, Conde Francisco, San-Segundo Pedro A, Bueno Avelino

Abstract excerpt

Regulation of PCNA ubiquitylation plays a key role in the tolerance to DNA damage in eukaryotes. Although the evolutionary conserved mechanism of PCNA ubiquitylation is well understood, the deubiquitylation of ubPCNA remains poorly characterized. Here, we show that the histone H2B(K123) ubiquitin protease Ubp10 also deubiquitylates ubPCNA in Saccharomyces cerevisiae. Our results sustain that Ubp10-dependent...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22829782
DOI: 10.1371/journal.pgen.1002826
PMCID: PMC3400564

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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