Article

Proteasome activator PA200 maintains stability of histone marks during transcription and aging

2020-04-30

Abstract excerpt

The epigenetic inheritance relies on stability of histone marks, but various diseases, including aging-related diseases, are usually associated with alterations of histone marks. How the stability of histone marks is maintained still remains unclear. The core histones can be degraded by the atypical proteasome, which contains the proteasome activator PA200, in an acetylation-dependent manner during somatic DNA dam...

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Literature Corpus work: e9449ba6-c307-5bb7-aa21-310a748e2d15
DOI: 10.1101/2020.04.28.067132

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