Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort.

Metabolism: clinical and experimental - 1 Oct 2009

Rasmussen-Torvik Laura J, Pankow James S, Jacobs David R, Sinaiko Alan R

Abstract excerpt

There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903146, a single nucleotide polymorphism found to be associated with type 2 diabetes mellitus in several genomewide association studies, and insulin sensitivity. The association of rs7903146 and euglycemic-clamp-derived insulin sensitivity was tested in a cohort of children and their parents. Four hundred seventy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aging
Share to Black or African American
Share to Black People
Share to Glucose Clamp Technique
Share to Insulin Resistance
Share to Longitudinal Studies
Share to TCF Transcription Factors
Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 19573884
DOI: 10.1016/j.metabol.2009.04.023
PMCID: PMC2748141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort.PMID 19573884Read ↗

Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.Semantic proximity Read ↗

Genetic variants of TCF7L2 are associated with insulin resistance and related metabolic phenotypes in Taiwanese adolescents and Caucasian young adults.Semantic proximity Read ↗

The TCF7L2 locus and type 1 diabetes.Semantic proximity Read ↗

Variants and haplotypes of TCF7L2 are associated with β-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.Semantic proximity Read ↗

Polymorphism in the Transcription Factor 7-Like 2 (TCF7L2) Gene Is Associated With Reduced Insulin Secretion in Nondiabetic WomenSemantic proximity Read ↗

Interrelationship of the rs7903146 TCF7L2 gene variant with measures of glucose metabolism and adiposity: The NEO study.Semantic proximity Read ↗

TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children.Semantic proximity Read ↗

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.Semantic proximity Read ↗

Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.Semantic proximity Read ↗

Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth.Semantic proximity Read ↗

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.Semantic proximity Read ↗

The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.