Article
TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Oct 2008
Roth C L, Hinney A, Reinehr T, Schreiner F, Nguyen T T, Müller T, Scholl C, Woelfle J, Karpushova A, Schäfer H, Nöthen M M, Hebebrand J
Abstract excerpt
Polymorphism RS7903146 in transcription factor 7-like2 gene ( TCF7L2) is associated with type 2-diabetes mellitus (T2DM) in adults. Concerned with predisposition for diabetes mellitus in obese children, we tested if risk genotypes TC and TT of rs7903146 are more common in obese children with increased homeostasis model assessment insulin resistance index (HOMA-IR) compared to obese controls with normal HOMA-IR....
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