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Article

Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.

The Journal of clinical endocrinology and metabolism - 1 Oct 2008

Wegner Lise, Hussain Meena S, Pilgaard Kasper, Hansen Torben, Pedersen Oluf, Vaag Allan, Poulsen Pernille

Abstract excerpt

OBJECTIVE: We investigated the regulation and metabolic effects of TCF7L2 gene expression in human sc fat and skeletal muscle and the impact of the TCF7L2, rs7903146, T-allele on gene expression and measures of glucose metabolism including insulin secretion and peripheral and hepatic insulin action. RESEARCH DESIGN AND METHODS: The rs7903146 was genotyped in 1) a population-based sample of 587 twins (55-64 yr)...

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Identifiers

PMID: 18611970
DOI: 10.1210/jc.2008-0855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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