Article
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.
Diabetes - 1 Oct 2006
Saxena Richa, Gianniny Lauren, Burtt Noël P, Lyssenko Valeriya, Giuducci Candace, Sjögren Marketa, Florez Jose C, Almgren Peter, Isomaa Bo, Orho-Melander Marju, Lindblad Ulf, Daly Mark J, Tuomi Tiinamaija, Hirschhorn Joel N, Ardlie Kristin G, Groop Leif C, Altshuler David
Abstract excerpt
Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased risk of type 2 diabetes in samples from Iceland, Denmark, and the U.S. We genotyped 13 single nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based and case-control designs from Scandinavia, Poland, and the U.S. We convincingly confirmed the previous association of TCF7L2 SNPs with the risk...
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