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Article

PI3K pathway alterations in cancer: variations on a theme.

Oncogene - 18 Sept 2008

Yuan T L, Cantley L C

Abstract excerpt

The high frequency of phosphoinositide 3-kinase (PI3K) pathway alterations in cancer has led to a surge in the development of PI3K inhibitors. Many of these targeted therapies are currently in clinical trials and show great promise for the treatment of PI3K-addicted tumors. These recent developments call for a re-evaluation of the oncogenic mechanisms behind PI3K pathway alterations. This pathway is unique in...

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Identifiers

PMID: 18794884
DOI: 10.1038/onc.2008.245
PMCID: PMC3398461

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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