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Article

PIK3CA gene aberrancy and role in targeted therapy of solid malignancies.

Cancer gene therapy - 1 Sept 2020

Willis Owen, Choucair Khalil, Alloghbi Abdurahman, Stanbery Laura, Mowat Rex, Charles Brunicardi F, Dworkin Lance, Nemunaitis John

Abstract excerpt

Phosphoinositide kinases (PIKs) are a group of lipid kinases that are important upstream activators of various signaling pathways that drive oncogenesis. Hyperactivation of the PI3K/AKT/mTOR pathways-either via mutations or genomic amplification-confers key oncogenic activity, essential for the development and progression of several solid tumors. Alterations in the PIK3CA gene are associated with poor prognosis...

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PMID: 31988478
DOI: 10.1038/s41417-020-0164-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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