Article
PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.
Cell cycle (Georgetown, Tex.) - 1 May 2009
Ligresti Giovanni, Militello Loredana, Steelman Linda S, Cavallaro Andrea, Basile Francesco, Nicoletti Ferdinando, Stivala Franca, McCubrey James A, Libra Massimo
Abstract excerpt
Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival and motility. The PI3K pathway is considered to play an important role in tumorigenesis. Activating mutations of the p110alpha subunit of PI3K (PIK3CA) have been identified in a broad spectrum of tumors. Analyses of PIK3CA mutations reveals that they increase the...
Topics
- Antineoplastic Agents
- Class I Phosphatidylinositol 3-Kinases
- Drug Screening Assays, Antitumor
- Humans
- Mutation
- Neoplasms
- Phosphatidylinositol 3-Kinases
- Signal Transduction