Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PI3K and AKT: Unfaithful Partners in Cancer

3 Sept 2015

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular processes. An overactivation of the pathway is frequently present in human malignancies and plays a key role in cancer progression. Hence, its inhibition has become a promising approach in cancer therapy. However, the development of resistances, such as the abrogation of negative feedback mechanisms or the activation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to CRISPR and Genetic Engineering
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26404259
DOI: 10.3390/ijms160921138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PI3K and AKT: Unfaithful Partners in CancerPMID 26404259Read ↗

The relation between PI3K/AKT signalling pathway and cancerSemantic proximity Read ↗

AKT in cancer: new molecular insights and advances in drug developmentSemantic proximity Read ↗

PI3K-Akt pathway: Its functions and alterations in human cancerSemantic proximity Read ↗

PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics.Semantic proximity Read ↗

The PKB/AKT pathway in cancer.Semantic proximity Read ↗

Current State and Future Challenges for PI3K Inhibitors in Cancer TherapySemantic proximity Read ↗

Akt: a key transducer in cancerSemantic proximity Read ↗

The PTEN–PI3K Axis in CancerSemantic proximity Read ↗

The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated ReviewSemantic proximity Read ↗

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancerSemantic proximity Read ↗

Targeting PI3K in cancer: mechanisms and advances in clinical trialsSemantic proximity Read ↗

The phosphatidylinositol 3-Kinase AKT pathway in human cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.