Article
Oncogenic PI3K and its role in cancer.
Current opinion in oncology - 1 Jan 2006
Samuels Yardena, Ericson Kajsa
Abstract excerpt
PURPOSE OF REVIEW: The purpose of this review is to examine the contribution of the PI3K signaling pathway to the development of human tumors and to propose further studies to elucidate how to develop therapeutics for patients with mutations in this pathway. RECENT FINDINGS: More than 30% of various solid tumor types were recently found to contain mutations in PIK3CA, the catalytic subunit of PI3K. Further...
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