Article
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt.
Cancer cell - 7 Jul 2009
Miao Hui, Li Da-Qiang, Mukherjee Amitava, Guo Hong, Petty Aaron, Cutter Jennifer, Basilion James P, Sedor John, Wu Jiong, Danielpour David, Sloan Andrew E, Cohen Mark L, Wang Bingcheng
Abstract excerpt
Both pro- and antioncogenic properties have been attributed to EphA2 kinase. We report that a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in regulating cell migration and invasion. While activation of EphA2 with its ligand ephrin-A1 inhibited chemotactic migration of glioma and prostate cancer cells, EphA2 overexpression promoted migration in a ligand-independent manner....
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