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Article

Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation.

Molecular cancer research : MCR - 1 Mar 2003

Lipinski Christopher A, Tran Nhan L, Bay Curtis, Kloss Jean, McDonough Wendy S, Beaudry Christian, Berens Michael E, Loftus Joseph C

Abstract excerpt

The propensity of malignant gliomas to invade surrounding brain tissue contributes to poor clinical outcome. Integrin-mediated adhesion to extracellular matrix regulates the migration and proliferation of many cell types, but its role in glioma progression is undefined. We investigated the role of the cytoplasmic tyrosine kinases FAK and Pyk2, potential integrin effectors, in the phenotypic determination of four...

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PMID: 12651906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation.PMID 12651906Read ↗

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Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer DevelopmentSemantic proximity Read ↗

Control of motile and invasive cell phenotypes by focal adhesion kinase.Semantic proximity Read ↗

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