Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival.

Journal of neuropathology and experimental neurology - 1 Dec 2006

Mizoguchi Masahiro, Betensky Rebecca A, Batchelor Tracy T, Bernay Derek C, Louis David N, Nutt Catherine L

Abstract excerpt

Diffuse astrocytic gliomas are the most common human glial tumors with glioblastoma being the most malignant form. Epidermal growth factor receptor (EGFR) gene amplification is one of the most common genetic changes in glioblastoma and can lead to the activation of various downstream signaling molecules, including STAT3, MAPK, and AKT. In this study, we investigated the activation status of these 3 signaling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Mitogen-Activated Protein Kinases

Share to Proto-Oncogene Proteins c-akt

Share to STAT3 Transcription Factor

Share to Survival Rate

Share to Transcriptional Activation

Source

Identifiers

PMID: 17146292
DOI: 10.1097/01.jnen.0000248549.14962.b2

Genes

STAT3
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival.PMID 17146292Read ↗

Targeting the AKT Pathway in GlioblastomaSemantic proximity Read ↗

Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in GliomasSemantic proximity Read ↗

STAT3 as a Therapeutic Target for GlioblastomaSemantic proximity Read ↗

Role of Akt in human malignant glioma: from oncogenesis to tumor aggressivenessSemantic proximity Read ↗

Astrocyte Elevated Gene-1 Interacts with Akt Isoform 2 to Control Glioma Growth, Survival, and PathogenesisSemantic proximity Read ↗

AKT2 expression is associated with glioma malignant progression and required for cell survival and invasionSemantic proximity Read ↗

Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progressionSemantic proximity Read ↗

STAT3 regulation of glioblastoma pathogenesis.Semantic proximity Read ↗

Nonredundant Functions for Akt Isoforms in Astrocyte Growth and Gliomagenesis in an Orthotopic Transplantation ModelSemantic proximity Read ↗

Activation of JAK/STAT signal pathway predicts poor prognosis of patients with gliomasSemantic proximity Read ↗

Analysis of PIK3CA and B-RAF gene mutations in human astrocytomas: association with activation of ERK and AKT.Semantic proximity Read ↗

Down-Regulation of Stat3 Decreases Invasion Activity and Induces Apoptosis of Human Glioma CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.