Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

1 Feb 2022

Abstract excerpt

Platelet-derived growth subunit A (PDGFA) plays critical roles in development of glioblastoma (GBM) with substantial evidence from TCGA database analyses and in vivo mouse models. So far, only platelet-derived growth receptor α (PDGFRA) has been identified as receptor for PDGFA. However, PDGFA and PDGFRA are categorized into different molecular subtypes of GBM in TCGA_GBM database. Our data herein further showed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Cell Adhesion Molecules Research
Share to Hippo pathway signaling and YAP/TAZ

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35105853
DOI: 10.1038/s41392-021-00855-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastomaPMID 35105853Read ↗

Platelet-derived growth factor receptor alpha in glioma: a bad seedSemantic proximity Read ↗

PDGF Family Expression in Glioblastoma Multiforme: Data Compilation from Ivy Glioblastoma Atlas Project DatabaseSemantic proximity Read ↗

Oncogenic long noncoding RNA LINC02283 enhances PDGF receptor A-mediated signaling and drives glioblastoma tumorigenesisSemantic proximity Read ↗

EGFR and PDGFRA co-expression and heterodimerization in glioblastoma tumor sphere linesSemantic proximity Read ↗

EphA2 as a Novel Molecular Marker and Target in Glioblastoma MultiformeSemantic proximity Read ↗

SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans.Semantic proximity Read ↗

Pathogenetic significance and possibility as a therapeutic target of platelet derived growth factorSemantic proximity Read ↗

Autocrine PDGF stimulation in malignancies.Semantic proximity Read ↗

Structural and functional specificities of PDGF‐C and PDGF‐D, the novel members of the platelet‐derived growth factors familySemantic proximity Read ↗

PDGFRA K385 mutants in myxoid glioneuronal tumors promote receptor dimerization and oncogenic signaling.Semantic proximity Read ↗

PDGF receptor signaling networks in normal and cancer cellsSemantic proximity Read ↗

New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.