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Article

The tyrosine kinase pyk2 promotes migration and invasion of glioma cells.

Neoplasia (New York, N.Y.) - 1 May 2005

Lipinski Christopher A, Tran Nhan L, Menashi Emmanuel, Rohl Carole, Kloss Jean, Bay R Curtis, Berens Michael E, Loftus Joseph C

Abstract excerpt

Glioblastoma multiforme is extraordinarily aggressive due to the propensity of cells to migrate away from the tumor core into the surrounding normal brain. In this report, we investigated the role of proline-rich tyrosine kinase 2 (Pyk2) and FAK with regard to influencing glioma cell phenotypes. Expression of Pyk2 stimulated glioma cell migration, whereas expression of FAK inhibited glioma cell migration and...

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Source

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Identifiers

PMID: 15967096
DOI: 10.1593/neo.04712
PMCID: PMC1501165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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