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Article

Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant glioma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2010

Li Xia, Wang Li, Gu Jian-Wen, Li Bing, Liu Wei-Ping, Wang Yan-Gang, Zhang Xiang, Zhen Hai-Ning, Fei Zhou

Abstract excerpt

Malignant gliomas display over-expression of the receptor tyrosine kinase EphA2. However, expression levels of the EphA2 ligand, EphrinA1, have not been fully elucidated. Seventy-eight patients with primary gliomas were included in this study who underwent surgical resection, radiation, and chemotherapy. The expression of EphA2 and EphrinA1 in tumors was assessed by immunohistochemistry and was statistically...

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PMID: 20571968
DOI: 10.1007/s13277-010-0060-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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