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Article

EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.

Nature communications - 7 Feb 2012

Li Guo, Ji Xiao-Dan, Gao Hong, Zhao Jiang-Sha, Xu Jun-Feng, Sun Zhi-Jian, Deng Yue-Zhen, Shi Shuo, Feng Yu-Xiong, Zhu Yin-Qiu, Wang Tao, Li Jing-Jing, Xie Dong

Abstract excerpt

Eph receptors are implicated in regulating the malignant progression of cancer. Here we find that despite overexpression of EphB3 in human non-small-cell lung cancer, as reported previously, the expression of its cognate ligands, either ephrin-B1 or ephrin-B2, is significantly downregulated, leading to reduced tyrosine phosphorylation of EphB3. Forced activation of EphB3 kinase in EphB3-overexpressing...

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PMID: 22314363
DOI: 10.1038/ncomms1675

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RACK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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