Article
Effects of N-glycosylation on the activity and localization of GlcNAc-6-sulfotransferase 1.
Glycobiology - 1 Oct 2009
Desko Marguerite M, Gross David A, Kohler Jennifer J
Abstract excerpt
N-Acetylglucosamine-6-sulfotransferase-1 (GlcNAc6ST-1) is a Golgi-resident glycoprotein that is responsible for sulfation of the l-selectin ligand on endothelial cells. Here, we report the sites at which GlcNAc6ST-1 is modified with N-linked glycans and the effects that each glycan has on enzyme activity, specificity, and localization. We determined that glycans are added at three of four potential N-linked...
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