Article
A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules.
Nature immunology - 1 Nov 2005
Uchimura Kenji, Gauguet Jean-Marc, Singer Mark S, Tsay Durwin, Kannagi Reiji, Muramatsu Takashi, von Andrian Ulrich H, Rosen Steven D
Abstract excerpt
The interaction of L-selectin on lymphocytes with sulfated ligands on high endothelial venules leads to rolling and is critical for recruitment of lymphocytes into peripheral lymph nodes. Peripheral node addressin represents a class of L-selectin ligands recognized by the function-blocking monoclonal antibody MECA-79. Its epitope overlaps with sialyl 6-sulfo Lewis X, an L-selectin recognition determinant. Here,...
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