Article
N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.
Nature immunology - 1 Nov 2005
Kawashima Hiroto, Petryniak Bronislawa, Hiraoka Nobuyoshi, Mitoma Junya, Huckaby Valerie, Nakayama Jun, Uchimura Kenji, Kadomatsu Kenji, Muramatsu Takashi, Lowe John B, Fukuda Minoru
Abstract excerpt
Lymphocyte homing is mediated by specific interactions between L-selectin on lymphocytes and sulfated carbohydrates restricted to high endothelial venules in lymph nodes. Here we generated mice deficient in both N-acetylglucosamine-6-O-sulfotransferase 1 (GlcNAc6ST-1) and GlcNAc6ST-2 and found that mutant mice had approximately 75% less homing of lymphocytes to the peripheral lymph nodes than did wild-type mice....
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