Article
Glycosyltransferase mutants: key to new insights in glycobiology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 1995
Stanley P, Ioffe E
Abstract excerpt
Glycosyltransferases (Glyc-T's) catalyze the synthesis of the carbohydrate portions of glycoproteins, glycolipids, and proteoglycans. Most Glyc-T's transfer one sugar in one linkage and are encoded by a unique gene. Thus, synthesis of a branched carbohydrate may require expression of at least 30 Glyc-T genes. Mutations that alter Glyc-T activity therefore provide an approach to identifying functions for...
Topics
- Animals
- Carbohydrate Conformation
- Carbohydrate Sequence
- Carbohydrates
- Cell Line
- Glycosylation
- Glycosyltransferases
- Humans
- Molecular Sequence Data
- Mutation
- Polysaccharides