Article
Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth.
Neoplasia (New York, N.Y.) - 1 May 2016
El Ghazal Roland, Yin Xin, Johns Scott C, Swanson Lee, Macal Monica, Ghosh Pradipta, Zuniga Elina I, Fuster Mark M
Abstract excerpt
In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However, little is known regarding the genetic and functional importance of glycan chains displayed by proteoglycans on dendritic cells (DCs) in cancer immunity. In lung carcinoma, among other solid tumors, tumor-associated DCs play largely subversive/suppressive...
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