Streamlining Sulfated Oligosaccharide and Glycan Synthesis with Engineered Mutant 6-SulfoGlcNAcases.

Abstract excerpt

Sulfation is a common, but poorly understood, post-glycosylational modification (PGM) used to modulate biological function. To deepen our understanding of the roles of various sulfated glycoforms and their relevant binding proteins, we must expand our enzymatic toolkit for their synthesis. Here, we bypass the need for both sulfotransferases and glycosyltransferases by engineering a series of mutants of a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Glycoside Hydrolases
• Share to Mutation