Article
Deletion of agouti-related protein blunts ethanol self-administration and binge-like drinking in mice.
Genes, brain, and behavior - 1 Jun 2009
Navarro M, Cubero I, Ko L, Thiele T E
Abstract excerpt
The melanocortin (MC) system is composed of peptides that are cleaved from the polypeptide precursor proopiomelanocortin (POMC). Recent pharmacological and genetic evidence suggests that melanocortin receptor (MCR) signaling modulates neurobiological responses to ethanol and ethanol intake. Agouti-related protein (AgRP) is synthesized by neurons in the arcuate nucleus of the hypothalamus and is a natural...
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