Article
Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2005
Bewick Gavin A, Gardiner James V, Dhillo Waljit S, Kent Aysha S, White Nicholas E, Webster Zoe, Ghatei Mohammad A, Bloom Stephen R
Abstract excerpt
Agouti-related protein (AgRP) and neuropeptide Y (NPY) are colocalized in arcuate nucleus (arcuate) neurons implicated in the regulation of energy balance. Both AgRP and NPY stimulate food intake when administered into the third ventricle and are up-regulated in states of negative energy balance. However, mice with targeted deletion of either NPY or AgRP or both do not have major alterations in energy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.