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Article

Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.

Endocrinology - 1 May 1999

Wilson B D, Bagnol D, Kaelin C B, Ollmann M M, Gantz I, Watson S J, Barsh G S

Abstract excerpt

Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice. Fasting associated with a decline in circulating leptin normally causes a 15-fold elevation of hypothalamic Agrp mRNA levels but has no effect in leptin-deficient mice. Chronic hyperleptinemia associated with the tubby and Cpe(fat)...

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Source

Identifiers

PMID: 10218993
DOI: 10.1210/endo.140.5.6728

Genes

AGRP
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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