Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.

doi:10.1210/endo.140.5.6728

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Article

Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.

Endocrinology - 1 May 1999

Wilson B D, Bagnol D, Kaelin C B, Ollmann M M, Gantz I, Watson S J, Barsh G S

Abstract excerpt

Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice. Fasting associated with a decline in circulating leptin normally causes a 15-fold elevation of hypothalamic Agrp mRNA levels but has no effect in leptin-deficient mice. Chronic hyperleptinemia associated with the tubby and Cpe(fat)...

Topics

Agouti Signaling Protein
Agouti-Related Protein
Animals
Arcuate Nucleus of Hypothalamus
Carrier Proteins
Fasting
Hypothalamus
Intercellular Signaling Peptides and Proteins
Leptin
Mice
Mice, Inbred C57BL
Mutation
Neurons
Obesity

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pro-Opiomelanocortin

Proteins

RNA, Messenger

Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 10218993
DOI: 10.1210/endo.140.5.6728

Genes

AGRP
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.