Article
Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice.
Molecular and cellular biology - 1 Jul 2002
Qian Su, Chen Howard, Weingarth Drew, Trumbauer Myrna E, Novi Dawn E, Guan Xiaoming, Yu Hong, Shen Zhu, Feng Yue, Frazier Easter, Chen Airu, Camacho Ramon E, Shearman Lauren P, Gopal-Truter Shobhna, MacNeil Douglas J, Van der Ploeg Lex H T, Marsh Donald J
Abstract excerpt
Agouti-related protein (AgRP), a neuropeptide abundantly expressed in the arcuate nucleus of the hypothalamus, potently stimulates feeding and body weight gain in rodents. AgRP is believed to exert its effects through the blockade of signaling by alpha-melanocyte-stimulating hormone at central nervous system (CNS) melanocortin-3 receptor (Mc3r) and Mc4r. We generated AgRP-deficient (Agrp(-/-)) mice to examine the...
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