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Article

Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.

Endocrinology - 1 May 2011

Corander Marcus P, Rimmington Debra, Challis Benjamin G, O'Rahilly Stephen, Coll Anthony P

Abstract excerpt

The hypothalamic melanocortin system is unique among neuropeptide systems controlling energy homeostasis, in that both anorexigenic proopiomelanocortin (POMC)-derived and orexigenic Agouti related-peptide (AgRP)-derived ligands act at the same receptors, namely melanocortin 3 and 4 receptors (MC3/4R). AgRP clearly acts as a competitive antagonist at MC3R and MC4R but may also have an inverse agonist action at...

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Source

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Identifiers

PMID: 21363936
DOI: 10.1210/en.2010-1450
PMCID: PMC3137464

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.PMID 21363936Read ↗

Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice.Semantic proximity Read ↗

The neuroendocrine circuitry controlled by POMC, MSH, and AGRP.Semantic proximity Read ↗

Melanocortins and body weight regulation: glucocorticoids, Agouti-related protein and beyond.Semantic proximity Read ↗

Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior.Semantic proximity Read ↗

The melanocortin action is biased toward protection from weight loss in miceSemantic proximity Read ↗

Agouti-related protein-deficient mice display an age-related lean phenotype.Semantic proximity Read ↗

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).Semantic proximity Read ↗

Pro-opiomelanocortin (POMC) Deficiency and Peripheral Melanocortins in ObesitySemantic proximity Read ↗

Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background.Semantic proximity Read ↗

Neuropeptides and obesity.Semantic proximity Read ↗

Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice.Semantic proximity Read ↗

Assessing interactions between Ghsr and Mc3r reveals a role for AgRP in the expression of food anticipatory activity in male mice.Semantic proximity Read ↗

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