Article
Assessment of voluntary ethanol consumption and the effects of a melanocortin (MC) receptor agonist on ethanol intake in mutant C57BL/6J mice lacking the MC-4 receptor.
Alcoholism, clinical and experimental research - 1 Jun 2011
Navarro Montserrat, Lerma-Cabrera Jose M, Carvajal Francisca, Lowery Emily G, Cubero Inmaculada, Thiele Todd E
Abstract excerpt
BACKGROUND: The melanocortin (MC) system is composed of peptides that are cleaved from the polypeptide precursor proopiomelanocortin (POMC). Recent evidence shows that chronic exposure to ethanol significantly blunts central MC peptide immunoreactivity and MC receptor (MCR) agonists protect against high ethanol intake characteristic of C57BL/6J mice. Here, we assessed the role of the MC-4 receptor (MC4R) in...
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