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Article

Hypothalamic-specific proopiomelanocortin deficiency reduces alcohol drinking in male and female mice.

Genes, brain, and behavior - 1 Apr 2017

Zhou Y, Rubinstein M, Low M J, Kreek M J

Abstract excerpt

Opioid receptor antagonist naltrexone reduces alcohol consumption and relapse in both humans and rodents. This study investigated whether hypothalamic proopiomelanocortin (POMC) neurons (producing beta-endorphin and melanocortins) play a role in alcohol drinking behaviors. Both male and female mice with targeted deletion of two neuronal Pomc enhancers nPE1 and nPE2 (nPE-/-), resulting in hypothalamic-specific...

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Identifiers

PMID: 27870313
DOI: 10.1111/gbb.12362
PMCID: PMC5553441

Genes

POMC

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