Article
Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor.
Alcoholism, clinical and experimental research - 1 Jun 2005
Navarro Montserrat, Cubero Inmaculada, Chen Airu S, Chen Howard Y, Knapp Darin J, Breese George R, Marsh Donald J, Thiele Todd E
Abstract excerpt
BACKGROUND: The melanocortin (MC) system is composed of peptides that are cleaved from the polypeptide precursor pro-opiomelanocortin. A growing body of literature suggests that the MC system modulates neurobiological responses to drugs of abuse. Because ethanol has direct effects on central pro-opiomelanocortin activity, it is possible that MC neuropeptides participate in the control of voluntary ethanol...
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