Article
Agouti-related protein-deficient mice display an age-related lean phenotype.
Cell metabolism - 1 Dec 2005
Wortley Katherine E, Anderson Keith D, Yasenchak Jason, Murphy Andrew, Valenzuela David, Diano Sabrina, Yancopoulos George D, Wiegand Stanley J, Sleeman Mark W
Abstract excerpt
Endogenous modulators of the central melanocortin system, such as the agouti-related protein (AgRP), should hold a pivotal position in the regulation of energy intake and expenditure. Despite this, AgRP-deficient mice were recently reported to exhibit normal food intake, body weight gain, and energy expenditure. Here we demonstrate that 2- to 3-month-old Agrp null mice do in fact exhibit subtle changes in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.