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Article

E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells

26 Jun 2009

Abstract excerpt

The generation of knock-out mice for E2F4 gene expression has suggested a role for this transcription factor in establishing and/or maintaining the intestinal crypt compartment. Having previously demonstrated that E2F4 is cytoplasmic in quiescent-differentiated cells but nuclear in growth factor-stimulated proliferative cells, the present study was aimed at determining the role of E2F4 in the control of human...

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PMID: 19562678
DOI: 10.1002/jcp.21859

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