Article
Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1.
Cancer letters - 1 Sept 2018
Li Shang-Ze, Zeng Feng, Li Jun, Shu Qi-Peng, Zhang Hui-Hui, Xu Jun, Ren Jian-Wei, Zhang Xiao-Dong, Song Xue-Min, Du Run-Lei
Abstract excerpt
Control of E2F1 activity is restricted via its interactions with RB1 and HDAC1. However, the detailed regulatory mechanisms underlying the E2F1/HDAC1 complex remain elusive. Here, we report that Nemo-like kinase (NLK) boosts cell cycle progression, which facilitates tumor development by releasing the E2F1 protein from HDAC1. Deletion of NLK largely blocks colorectal tumor proliferation and development. Moreover,...
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