Article

Tumor suppressor Hypermethylated in Cancer 1 represses expression of cell cycle regulator E2F7 in human primary cells

2022-07-25

Abstract excerpt

Hypermethylated in Cancer 1 (HIC1) is an established tumor suppressor, which is frequently inactivated in various cancers. In colorectal carcinoma (CRC), silencing of HIC1 has been recognized as one of the important events in malignant tumor progression. Strikingly, CRC patients with high HIC1 expression have a worse prognosis than patients with relatively low HIC1 mRNA levels. To analyze the function of HIC1, we...

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Literature Corpus work: 2edcc078-96db-56d1-9949-b1636594c6ba
DOI: 10.1101/2022.07.25.501405

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