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Article

Functional impact of colorectal cancer-associated mutations in the transcription factor E2F4.

International journal of oncology - 1 Dec 2013

Paquin Marie-Christine, Leblanc Caroline, Lemieux Etienne, Bian Benjamin, Rivard Nathalie

Abstract excerpt

The transcription factor E2F4 plays a critical role in cell cycle progression of normal and cancerous intestinal epithelial cells. Contrary to other E2Fs, the coding region of the E2F4 gene contains a longer spacer segment of a CAG trinucleotide repeat sequence encoding 13 consecutive serine residues, which is highly vulnerable to frameshift mutations in situations of genetic instability. Mutations in this region...

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Identifiers

PMID: 24100580
DOI: 10.3892/ijo.2013.2131

Genes

RBL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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