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Article

p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.

Gastroenterology - 1 Jul 2007

Smartt Helena J M, Guilmeau Sandra, Nasser Shannon V, Nicholas Courtney, Bancroft Laura, Simpson Sharon A, Yeh Nancy, Yang Wancai, Mariadason John M, Koff Andrew, Augenlicht Leonard H

Abstract excerpt

BACKGROUND & AIMS: Reduced p27(kip1) expression is a marker of poor prognosis in colorectal neoplasia, and inactivation of p27 in mice (p27(Delta51/Delta51)) causes increased intestinal epithelial cell proliferation and small and large intestinal neoplasia in a diet-dependent manner. Here, we addressed the role of p27 in untransformed intestinal epithelial cells in vivo and the consequence of its targeted...

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PMID: 17631145
DOI: 10.1053/j.gastro.2007.04.043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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